Zurier R B, Weissmann G, Hofistein S, Kainmerman S & Tai H IL Mechanisms of lysosomal enzyme release from human [eukocytes. Il. Effects of cAMP and cGMP,autonomc agonists, and agents which affect microtubule function. J. Clin. Invest. 53:297-309, 1974

selective release of inflammatory materials from lysosomes of human peripheral blood polyrnorphonuclear leukocytes is reduced by compounds that increase cyclic AMP and is augmented by agents that increase cyclic GMP concentrations in the cells. In addition, the results indicate that impairment of mlcrotubule integrity reduces selective release of lysosomal enzymes whereas compounds that favor microtubule assembly enhance enzyme release. [The SC!® indicates that this paper has been cited in over 515 publications.]